Abstract: Medical polymers have given tremendous contribution to human health and social progress. However，it has been recognized that the misunderstanding or inappropriate selection for polymeric materials would bring new disease sources and risks for human health. The present review provides a systematic summary for the potential hazards of medical infusion and blood storage and transfusion prepared with polyvinyl chloride（PVC）to human health and environment. Replacement of PVC with modified polyolefin alloys for the manufacture of these medical devices is also introduced，providing with their characterization of physical，chemical and biological properties. Furthermore，the developing trends for medical polymeric materials are discussed.