Abstract: A series of CuCoO_x catalysts supported on TiO₂ were prepared by impregnation for catalytic CO oxidation. The results of XRD and TPR analysis and BET testing showed that the catalyst calcined at 350℃ has a spinel structure of CuCo₂O₄ having a larger specific surface area and a better catalytic efficiency. At 110℃, CO with 1% concentration can be completely oxidized into CO₂. Effects of calcination temperature, reaction temperature, CO concentration, space velocity as well as the influence of SO₂ and H₂O on CO conversion have been investigated. The prepared catalyst has good poison resistance against SO₂ and H₂O, which can be used for removing CO from flue gas that contains either SO₂ or H₂O