Abstract:

D-glucaric acid is a dicarboxylic acid containing polyhydroxy. It can be obtained from many glucose-based substances and be used to prepare products of biodegradable polymers，pharmaceuticals and food. In this review，we try to describe the principles and preparation methods of D-glucaric acid in both chemical（nitric acid oxidation and TEMPO oxidation）and biological fields，and review its applications in both pharmaceuticals（anticancer drugs and imaging agents）and polymers.