Nanoencapsulation of Lutein with Hydroxypropylmethyl Cellulose Phthalate by Supercritical Antisolvent

CIESC Journal ›› 2009, Vol. 17 ›› Issue (4): 672-677.

Nanoencapsulation of Lutein with Hydroxypropylmethyl Cellulose Phthalate by Supercritical Antisolvent

金鹤阳¹, 夏菲¹, 江翠兰¹, 赵亚平¹, 何琳²

1. School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China;
2. Analysis Center of Shanghai Jiao Tong University, Shanghai 200240, China

收稿日期:2008-12-02 修回日期:2009-03-28 出版日期:2009-08-28 发布日期:2010-12-30
通讯作者: ZHAO Yaping, E-mail: ypzhao@sjtu.edu.cn
作者简介:
基金资助:
Supported by the National High Technology Research and Development Program of China(2007AA10Z350)

Nanoencapsulation of Lutein with Hydroxypropylmethyl Cellulose Phthalate by Supercritical Antisolvent

JIN Heyang¹, XIA Fei1¹, JIANG Cuilan¹, ZHAO Yaping¹, HE Lin²

1. School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China;
2. Analysis Center of Shanghai Jiao Tong University, Shanghai 200240, China

Received:2008-12-02 Revised:2009-03-28 Online:2009-08-28 Published:2010-12-30
Supported by:
Supported by the National High Technology Research and Development Program of China(2007AA10Z350)

摘要/Abstract

摘要： Lutein was nano-encapsuled with hydroxypropylmethyl cellulose phthalate(HPMCP) to maintain its bioactivity and to avoid thermal/light degradation.Supercritical antisolvent precipitation was applied to prepare lutein/HPMCP nano-capsule.The effects of several operating parameters on the yield,lutein loading,encapsulation efficiency,particle size and particle size distribution of the nanocapsule were investigated.The mean diameter of nanocapsules ranged from 163nm to 219nm under appropriate experimental conditions.The result of scanning electron microscope showed that the nanocapsules were nearly spherical.The highest yield reached 95.35% when the initial concentration of lutein was saturated.The highest lutein loading of 15.80% and encapsulation efficiency of 88.41% were obtained under the conditions of 11MPa,40℃ and C_HPMCP:C_lutein=5:l.The results may promote the application of lutein in food industry.

关键词: nanocapsule, lutein, hydroxypropylmethyl cellulose phthalate, supercritical antisolvent precipitation

Abstract: Lutein was nano-encapsuled with hydroxypropylmethyl cellulose phthalate(HPMCP) to maintain its bioactivity and to avoid thermal/light degradation.Supercritical antisolvent precipitation was applied to prepare lutein/HPMCP nano-capsule.The effects of several operating parameters on the yield,lutein loading,encapsulation efficiency,particle size and particle size distribution of the nanocapsule were investigated.The mean diameter of nanocapsules ranged from 163nm to 219nm under appropriate experimental conditions.The result of scanning electron microscope showed that the nanocapsules were nearly spherical.The highest yield reached 95.35% when the initial concentration of lutein was saturated.The highest lutein loading of 15.80% and encapsulation efficiency of 88.41% were obtained under the conditions of 11MPa,40℃ and C_HPMCP:C_lutein=5:l.The results may promote the application of lutein in food industry.

Key words: nanocapsule, lutein, hydroxypropylmethyl cellulose phthalate, supercritical antisolvent precipitation

金鹤阳, 夏菲, 江翠兰, 赵亚平, 何琳. Nanoencapsulation of Lutein with Hydroxypropylmethyl Cellulose Phthalate by Supercritical Antisolvent[J]. CIESC Journal, 2009, 17(4): 672-677.

JIN Heyang, XIA Fei1, JIANG Cuilan, ZHAO Yaping, HE Lin. Nanoencapsulation of Lutein with Hydroxypropylmethyl Cellulose Phthalate by Supercritical Antisolvent[J]. , 2009, 17(4): 672-677.

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Nanoencapsulation of Lutein with Hydroxypropylmethyl Cellulose Phthalate by Supercritical Antisolvent

Nanoencapsulation of Lutein with Hydroxypropylmethyl Cellulose Phthalate by Supercritical Antisolvent

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