运用手性固定相研究外消旋布洛芬的光学分离

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运用手性固定相研究外消旋布洛芬的光学分离

Dalkeun PARK^a; Joong Kee LEE^a; So-Young KIM^a; Taeho SONG^a; Sung-Sup SUH^b

^a Nano-Eco Research Center, KIST, Seoul 136-791, Korea
^b Chemical Engineering Department, Hongik University, Seoul 121-791, Korea

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2002-12-28 发布日期:2002-12-28
通讯作者: Dalkeun PARK

Comparative Optical Separation of Racemic Ibuprofen by Using Chiral Stationary Phase

Dalkeun PARK^a; Joong Kee LEE^a; So-Young KIM^a; Taeho SONG^a; Sung-Sup SUH^b

^a Nano-Eco Research Center, KIST, Seoul 136-791, Korea
^b Chemical Engineering Department, Hongik University, Seoul 121-791, Korea

Received:1900-01-01 Revised:1900-01-01 Online:2002-12-28 Published:2002-12-28
Contact: Dalkeun PARK

摘要/Abstract

摘要： Ibuprofen is widely used as a non-steroidal anti-inflammatory drug and produced as racemic
mixture. Its pharmacological activity resides only in S-(+)-enantiomer, and R-(-)-
enantiomer is not only inactive but also has many side effects. Thus it is necessary to
separate Renanfiomer from racemic ibuprofen. We studied optical separation of racemic
Ibuprofen with chiral high performance liquid chromatography (HPLC). Out of three different
chiral stationary phases, which were selected on the basis of structure and availability,
two were found to be effective. There was optimum eluent composition for each stationary
phase for good resolution in optical separation. Resolution decreased with increase of
eluent flow rate, but effect of injection volume on resolution was insignificant at high
eluent flow rate.

关键词: ibuprofen;enantiomer;separation;high performance liquid chromatography;chiral stationary phase

Abstract: Ibuprofen is widely used as a non-steroidal anti-inflammatory drug and produced as racemic
mixture. Its pharmacological activity resides only in S-(+)-enantiomer, and R-(-)-
enantiomer is not only inactive but also has many side effects. Thus it is necessary to
separate Renanfiomer from racemic ibuprofen. We studied optical separation of racemic
Ibuprofen with chiral high performance liquid chromatography (HPLC). Out of three different
chiral stationary phases, which were selected on the basis of structure and availability,
two were found to be effective. There was optimum eluent composition for each stationary
phase for good resolution in optical separation. Resolution decreased with increase of
eluent flow rate, but effect of injection volume on resolution was insignificant at high
eluent flow rate.

Key words: ibuprofen, enantiomer, separation, high performance liquid chromatography, chiral stationary phase

Dalkeun PARK, Joong Kee LEE, So-Young KIM, Taeho SONG, Sung-Sup SUH. 运用手性固定相研究外消旋布洛芬的光学分离[J]. CIESC Journal.

Dalkeun PARK, Joong Kee LEE, So-Young KIM, Taeho SONG, Sung-Sup SUH. Comparative Optical Separation of Racemic Ibuprofen by Using Chiral Stationary Phase[J]. .

参考文献

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运用手性固定相研究外消旋布洛芬的光学分离

Comparative Optical Separation of Racemic Ibuprofen by Using Chiral Stationary Phase

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