CIESC Journal

• RESEARCH PAPERS •    下一篇

一水盐酸环丙沙星初级成核机理的研究

王静康; 刘勇; 尹秋响   

  1. School of Chemical Engineering and Technology, Tianjin University, Tianjin,300072, China
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2002-08-28 发布日期:2002-08-28
  • 通讯作者: 王静康

Studies on the Mechanism of Primary Nucleation of Ciprofloxacin Hydrochloride Monohydrate

WANG Jingkang; LIU Yong; YIN Qiuxiang   

  1. School of Chemical Engineering and Technology, Tianjin University, Tianjin,300072, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2002-08-28 Published:2002-08-28
  • Contact: WANG Jingkang

摘要: A general expression for the relationship between induction period and supersaturation was
developed based on polynuclear approach. Different mechanism of primary nucleation in
solution can be illustrated by the expression. The results of induction period determined
by laser scattering method shows that the crystallization of ciprofloxacin hydrochloride
monohydrate in water/ethanol or aqueous solution is by the mechanism of primary nucleation
followed by one-dimensional diffusion growth, and then one-dimensional continuous or "birth
and spread"growth on crystal face. The growth mechanism on the crystal face is affected by
temperature and solvent.

关键词: ciprofloxacin hydrochloride monohydrate;induction period;primary nucleation;diffusion growth;continuous growth;"birth and spread" growth

Abstract: A general expression for the relationship between induction period and supersaturation was
developed based on polynuclear approach. Different mechanism of primary nucleation in
solution can be illustrated by the expression. The results of induction period determined
by laser scattering method shows that the crystallization of ciprofloxacin hydrochloride
monohydrate in water/ethanol or aqueous solution is by the mechanism of primary nucleation
followed by one-dimensional diffusion growth, and then one-dimensional continuous or "birth
and spread"growth on crystal face. The growth mechanism on the crystal face is affected by
temperature and solvent.

Key words: ciprofloxacin hydrochloride monohydrate, induction period, primary nucleation, diffusion growth, continuous growth, birth and spread growth