化工学报 ›› 2005, Vol. 56 ›› Issue (10): 2024-2028.
• 材料科学与工程 • 上一篇 下一篇
高迎春;张亮;卞正中
出版日期:
发布日期:
GAO Yingchun;ZHANG Liang;BIAN Zhengzhong
Online:
Published:
关键词: 卡托普利, 混合骨架片, 体外释放度, 蜡质888
Abstract: The effects of different matrix material contents on the release of soluble drug’s mixed matrix were studied.With dissolution as guideline,and Captopril as model drug the effect of matrix material contents on the release of Captopril from hydrophilic gel matrix, wax matrix and mixed matrix were compared.The content of the matrix material had greater influence on the release of Captopril from mixed matrix than that from former single matrix. Moreover, the effect of Compritol 888 contents was more significant than that of HPMC K4M in mixed matrix.
Key words: 卡托普利, 混合骨架片, 体外释放度, 蜡质888
高迎春, 张亮, 卞正中. 缓释材料用量对水溶性药物骨架片释放度的影响 [J]. 化工学报, 2005, 56(10): 2024-2028.
GAO Yingchun, ZHANG Liang, BIAN Zhengzhong. Effects of matrix material content on soluble drug release from matrix[J]. CIESC Journal, 2005, 56(10): 2024-2028.
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