Abstract: A novel model was presented to describe the mass transfer from an oscillating microdroplet.Based on the periodical flow field induced by an oscillating microdroplet and the basic mass transfer conservation equation, a simplified mass transfer control equation was derived and the corresponding concentration distribution was obtained by means of numerical technique.The simulated results showed the uneven characteristics in the concentration distribution.The gradients of concentration on upwind side of the microdroplet were much greater than those on downwind side.The simulated average Sherwood numbers and the rates of mass transfer were increasing with increasing oscillatory frequency.The trends of simulated Sherwood numbers were consistent with the experimental results of evaporation of an oscillating dodecanol microdroplet in the nitrogen media at a low evaporation rate, where the microdroplet was electrodynamically levitated and forced to oscillate in a nearly sine pattern along the central axis of an electrodynamic balance.The average error of predicted Sherwood numbers was 39.5%. It indicates that the present model is capable of describing the phenomena of mass transfer from the surface of a single oscillating microdroplet.