Abstract: To design a novel pervaporation membrane reactor for cyclohexane oxidation，based on the solubility parameter theory，solubility interactions between polymers and solvents were compared to select potential appropriate membrane materials for the separation of cyclohexanol (cyclohexanone)/ cyclohexane mixtures. Solubility interactions between thirty polymers and the three solvents，i.e. cyclohexanol，cyclohexanone and cyclohexane，were plotted using the combined component parameter and the hydrogen(H) bonding component parameter. Hydrogen-bonding interaction and the distance between the vector end point of solvents and polymers were investigated. From the preliminary analysis，PA-66，PVP，PEG，CTA and CA were considered to be potential appropriate membrane materials.