Abstract: This review reflects mainly the research on the phosphatidylcholine analogous polymers， including both side-chain type and main-chain type. The polymers，which have the zwitterionic lipid phosphatidylcholine，possess excellent blood compatibility and high hydrophilicity. Their applications in the fields of biomedicine，biochemistry and cosmetic are discussed，including their usage as non-thrombogenic material，drug delivery nanoparticles，gene carrier，biosensors and artificial organs etc.