Abstract: A new plate-to-plate method for performance prediction of azeotropic distillation processes is developed. Azeotropic distillation is characterized by the strong interaction among components and by a small number of components involved. By plate-to-plate method, the number of iterative variables depends only on the number of components, therefore a combination of the plate-to-plate approach and the Newton-Raphson convergence method is suggested for the calculation of azotropic distillation processes. According to the mono-tonicity principle proposed, mole fractions of components or ratios of these fractions are selected as iterative variables to obtain stable and rapid convergences. As a result, this method has been successfully applied for calculating a number of typical azeotropic distillation processes.