Abstract: Mixing beat data were measured at three different temperatures by PICKER dynamic liquid flow micro-calorimeter for eight binary systems consisting of hydrocarbon and alcohol. A new thermodynamic model-Quasi Chemical Solution Model (QCSM) was suggested to study the thermodynamic properties of hydrocarbon-alcohol systems. The experimental data of mixing heat and isothermal vapor-liquid equilibria of some systems were correlated by the QCSM. The agreements between calculated and experimental data were satisfactory. From QCSM parameters and their relationships with temperature which were fitted in with heat of mixing, the 244 isothermal or isobaric vapor-liquid equilibrium data for 8 hydrocarbon-alcohol binary systems were predicted. Good results were obtained, and the average deviations of vapor phase mole fraction were within 0.004-0.032.