Abstract: The nonisothermal effectiveness fcator for reaction with kinetics r=kc~m/(l+Kc)~a can be improved bycatalysts with nonuniform activity distribution.The optimal distribution function in one-dimensional modelwith which the effectiveness factor can be maximized is a δ-function which means that the activity of thecatalyst should be concentrated on a layer with negligible thickness in a precise locationfrom the centerof pellets.The general equations for predicting the value ofand maximum effectiveness factor as a functionof thermodynamic,kinetic and transport parameters are derived and they can be given explicitly in the case ofa=O,m=a or isothermal reaction.An active layer with definite thickness and a deviation from the optimal locationboth decrease thevalue of the effectiveness factor.It has been shown numerically that the effectiveness factor decreases slightlywith an active layer at the inner side of x but seriously at outer side.