Abstract: In this paper,we consider the process development and scaling up of trickle-bed reactor for 1,4-butynediolsynthesis.Three laboratory chemical reactors have been used,i.e.,a batchwise stirred kettle for the de--termination of intrinsic kinetics,a continuous rotating basket reactor for macrokinetics of large catalystpellets,and an external recycle differential trickle-bed reactor for bed-kinetics under liquid flow rates of in-dustrial equipment.The kinetic data obatined from above three reactors can be correlated in power form rate equations,and the results not only present definite proof of the relationships between contacting effectiveness factorsand liquid flow rates developed by Satterfield,but also verify the influences of liquid flow rates under higherand lower temperatures.The external contacting effectiveness factors in trickle-bed reactor we determined can be used to correctthe macrokinetic models of catalyst pellets determined from rotating basket,and the corrected kinetic modelscan be checked by an adiabatic pilot equipment with rather successful results.