Abstract: Previous work on the optimal activity distribution in catalyst pellets for the nonisothermal A→B reactions is extended to the nonisothermal two-component reactions with the kinetics r=kc_A~(m_1)c_B~(m_2)/(1+K_Ac_A+K_Bc_B)~a and some concepts are generalized. It is shown that the optimal activity distribution is also a Dirac delta function. The optimal location depends on nonisothermal effect parameter βγ, concentration sensitivity parameter πand Thiele modulus φ. A criterion is derived to evaluate the optimal location whether within the pellet or at the external surface. The influences of both the increase of the active layer thickness and the deviation of the active layer location from the optimal location are analysed. The effectiveness factors of pellets are more sensitive to the location than to the thickness.