Abstract: A temperature-dependent association model (TDAM) based on the association solution theory was established to describe the excess enthalpy, HE, for the alcohol-containing systems. For a particular system, the system dependent parameters, A and B, were related to HE as follows: The relation between temperature and association heat, ΔH, was expressed as: where only three parameters, A, B, and ΔH, were needed. By interpolating the HE data of two temperatures, the HE data for the other temperatures could be predicted. The results correlated by the TDAM gave better agreement with experimental data than those by the QCSM and WILSON Models. The TDAM model can be used for predicting excess enthalpy and vapor -liquid equilibria with satisfactory results.