Abstract: The ETDF-PR equation of state proposed in Part( I )of this work was extended to the vapor-liquid equilibria of mixtures. A comprehensive mixing rule and fugacity coefficient expression were proposed, which can be simplified into different versions for the specific systems. Binary and ternary VLE for nonpolar-nonpolar, nonpolar-polar, polar-polar systems (mainly alcohol-containing systems) at moderate and high pressures were calculated with satisfactory accuracy. Moreover, a method to handle the supercritical component for the ETDF-PR equation was presented, and used for hydrogen-containing systems successfully. In conclusion, a practical procedure for describing VLE for complex systems was suggested in this work. Apparently, this procedure can be applied to the process development for the separation of the higher alcohols and other real systems.