Abstract: This paper describes the necessity of simultaneously considering flow exer-gy dissipation of heat exchanger, optimization of match unit and heat transfer enhancement while searching optimal minimum temperature approach ΔTmin,opt. It is proposed through analysis to take the ΔT°min,oPt obtained with Linnhoff et al. s "supertargeting" as the initial value and search the ΔTmin, opt towards a value larger than the ΔT°min,opt in order to save computation time. In this paper, economic margin and composite curves structure characteristics of heat exchanger system influencing the ΔTmin,opt and its difference with the initial value are discussed, 4 typical types of composite curves structure are distinguished. A new strategy for heat exchanger network synthesis is advanced. Three practical cases show the advantage of the new strategy over others.