Abstract: As a new type of catalyst-capsule for synthesis of methyl tert-butyl ether with catalytic distillation, the catalyst particles (40 mesh)are packed in a capsule made of stainless steel mesh. The capsule is 200mm in length and 20-100mm in diameter. The chemical reaction takes place under distillation condition. The effective factor and the apparent reaction rate constant of catalyst-capsule were determined. By means of a mathematical model, the effective factors of catalyst-capsule with various diameters and at various temperatures were calculated. The results provide useful help for design of catalytic distillation columns.