Abstract: In this article the non-equilibrium stage model is modified and used for processsimulation of catalytic distillation, which consists of rectifying and stripping sections with conventional structures of a packed column and a reaction section with catalyst bed specially packed, as proposed by CR&L Co. The mass transfer rate in the reaction section is calculated by using gas and liquid film mass transfer coefficients specially measured for this structure of catalyst bed and the mass transfer rates in the rectifying and stripping sections are calculated by using Ondas correlation. The process simulation of synthesis of cellosolve with catalytic distillation is accomplished on the basis of the kinetic equation of reaction between ethanol and ethylene oxide on molecular sieve catalyst NKC-01 and the Newton-Raphson technique The results are satisfactory.