A NEW TWO-COMPARTMENT MODEL OF PATIENT-ARTIFICIAL KIDNEY SYSTEM INCLUDING CSF COMPARTMENT

CIESC Journal

A NEW TWO-COMPARTMENT MODEL OF PATIENT-ARTIFICIAL KIDNEY SYSTEM INCLUDING CSF COMPARTMENT

张凤宝¹; 张国亮¹; 王绍亭¹; 姜埃利²; 刘建勇³; 马腾骧³

¹ Department of Chemical Engineering, Institute of Biomedical Engineering, Tianjin University, Tianjin 300072, China

² Research Center of Hemopurification, Tianjin Medical College, Tianjin 300211, China

³ Tianjin Institute of Urological Surgery, Tianjin 300211, China

收稿日期:1993-01-18 修回日期:1993-04-06 出版日期:1994-12-28 发布日期:1994-12-28
通讯作者: 张凤宝

A NEW TWO-COMPARTMENT MODEL OF PATIENT-ARTIFICIAL KIDNEY SYSTEM INCLUDING CSF COMPARTMENT

ZHANG Fengbao¹; ZHANG Guoliang¹; WANG Shaoting¹; JIANG Aili²; LIU Jianyong³; MA Tengxiang³

¹ Department of Chemical Engineering, Institute of Biomedical Engineering, Tianjin University, Tianjin 300072, China

² Research Center of Hemopurification, Tianjin Medical College, Tianjin 300211, China

³ Tianjin Institute of Urological Surgery, Tianjin 300211, China

Received:1993-01-18 Revised:1993-04-06 Online:1994-12-28 Published:1994-12-28
Contact: ZHANG Fengbao

摘要/Abstract

摘要： A two-compartment model of patient-artificial kidney system consisting of a cerebrospinalfluid(CSF)and a body liquor compartments have been presented.With the model,the mechanism ofdisequilibrium syndrome occurred in a patient undergoing hemodialysis has been discussed to simulatethe CSF pressure transients.Urea,as an uretic toxin,was injected into dogs and in vivohemodialysis experiments have been performed under clinical conditions.The parameters in the sol-ution,G and K,have been determinde from experiments and are in good agreement with those re-ported under normal physiological conditions and in previous investigations.

关键词: hemodialysis;compartment model;cerebrospinal fluid;modelling

Abstract: A two-compartment model of patient-artificial kidney system consisting of a cerebrospinalfluid(CSF)and a body liquor compartments have been presented.With the model,the mechanism ofdisequilibrium syndrome occurred in a patient undergoing hemodialysis has been discussed to simulatethe CSF pressure transients.Urea,as an uretic toxin,was injected into dogs and in vivohemodialysis experiments have been performed under clinical conditions.The parameters in the sol-ution,G and K,have been determinde from experiments and are in good agreement with those re-ported under normal physiological conditions and in previous investigations.

Key words: hemodialysis, compartment model, cerebrospinal fluid, modelling

张凤宝, 张国亮, 王绍亭, 姜埃利, 刘建勇, 马腾骧. A NEW TWO-COMPARTMENT MODEL OF PATIENT-ARTIFICIAL KIDNEY SYSTEM INCLUDING CSF COMPARTMENT[J]. CIESC Journal.

ZHANG Fengbao, ZHANG Guoliang, WANG Shaoting, JIANG Aili, LIU Jianyong, MA Tengxiang. A NEW TWO-COMPARTMENT MODEL OF PATIENT-ARTIFICIAL KIDNEY SYSTEM INCLUDING CSF COMPARTMENT[J]. .

A NEW TWO-COMPARTMENT MODEL OF PATIENT-ARTIFICIAL KIDNEY SYSTEM INCLUDING CSF COMPARTMENT

A NEW TWO-COMPARTMENT MODEL OF PATIENT-ARTIFICIAL KIDNEY SYSTEM INCLUDING CSF COMPARTMENT

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