Abstract: A new process of condensation reaction ?separation of phenol and acetone in multi-stages trickle bed reactor has been developed. The problems of the fixed bed reactor with resin catalyst in production of BPA were resolved successfully. The influence of the technological conditions on condensation effect, such as reaction temperature, molar ratio of phenol to acetone, residence time and nitrogen flow rate was analyzed. The produced water was stripped and separated by nitrogen, the reaction temperature and molar ratio of phenol to acetone in the multistages trickle bed reactor were well distributed. By even mixing of the granulated packing with the catalyst, the transfer processes were intensified and the pressure drop of catalyst layers was cut down. Model experiment showed that the reaction and separation process in production of BPA with the multistages trickle bed reactor caused high concentration of condensation product, high conversion, high selectivity and high capacity of catalyst. The applicable range of reaction-separation process was extended.