Abstract: The approach recently proposed by Liu and Qu was extended to correlate excess enthalpies of highly asymmetric binary systems.In this approach,FRKS equation of state was used, and L_(ij)(T,x)function was applied in place of single value of the binary interaction parameter L_(ij).Twenty four binary systems,including benzene -（C_(11)～C_(17)）lakane,benzene -methyl naphthalene,xylene-(C_3～C_8)al-cohol,l-Hepetanol-(C_6～C_9)alkane,methanol,ethanol-chlorobenzene,were selected to do the test.For most of these binary systems, no equation of state method has been found accurate.The results obtained show that this method can improve significantly the correlation of excess enthalpies for highly asymmetric binary systems.The calculated excess enthalpies for most of the selected systems are in good agreement with experimental data.