Abstract: Based on the models and computation method developed in the part (Ⅰ),this paper analyses the effects of operation conditions on the time dependent variations of different kinds of oxygen and the performance of the CFB reactor system. The simulation and analysis lead to the following conclusions regarding to the performance of the riser-regenerator two bed system for selective oxidation of n-butane to maleic anhydride over the VPO catalyst. The reaction performance in the riser is strongly influenced by gas phase feed compositions and solid phase oxygen loading. It is also demonstrated that an improved selectivity and yield for maleic anhydride can be achieved by elevating regeneration temperature so as to enhance the oxygen uptake rate and to optimize distribution of different types of oxygen sites over the catalysts. At the same time, the solids circulation flux through the system can largely be reduced.