CIESC Journal

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扩散控制型混合药膜包膜体系缓释的数学模型

张国亮; 石巍; 张凤宝; 刘瑛   

  1. School of Chemical Engineering & Technology, Tianjin University, Tianjin 300072, China
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2001-03-28 发布日期:2001-03-28
  • 通讯作者: 张国亮

A Mathematical Model for Diffusion-Controlled Monolithic Matrix Coated with outer Membrane
System

ZHANG Guoliang; SHI Wei; ZHANG Fengbao; LIU Ying   

  1. School of Chemical Engineering & Technology, Tianjin University, Tianjin 300072, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2001-03-28 Published:2001-03-28
  • Contact: ZHANG Guoliang

摘要: A release model for diffusion-controlled monolithic matrix coated with outer membrane
system is proposed and solved by using the refined double integral method. The calculated
results are in satisfactory agreement with the experimental release data. The present model
can be well used to describe the release process for all cd/cs values. In addition, the
release effects of the monolithic matrix coated with outer membrane system are discussed
theoretically.

关键词: controlled release;diffusion;mercaptopurinum;monolithic matrix;outer membrane

Abstract: A release model for diffusion-controlled monolithic matrix coated with outer membrane
system is proposed and solved by using the refined double integral method. The calculated
results are in satisfactory agreement with the experimental release data. The present model
can be well used to describe the release process for all cd/cs values. In addition, the
release effects of the monolithic matrix coated with outer membrane system are discussed
theoretically.

Key words: controlled release, diffusion, mercaptopurinum, monolithic matrix, outer membrane