环丙沙星合成的新方法

CIESC Journal

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环丙沙星合成的新方法

陈英奇; 戴立言

College of Material and Chemical Engineering, Zhejiang University, Hangzhou 310027, China

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2001-09-28 发布日期:2001-09-28
通讯作者: 陈英奇

New Synthetic Method of Ciprofloxacin

CHEN Yingqi; DAI Liyan

College of Material and Chemical Engineering, Zhejiang University, Hangzhou 310027, China

Received:1900-01-01 Revised:1900-01-01 Online:2001-09-28 Published:2001-09-28
Contact: CHEN Yingqi

摘要/Abstract

摘要： A new synthetic method of ciprofloxacin is started with 2,4-dichloro-5-fluoroacetophenone,
via oxaly lation, ethoxymethylenation, amination, cyclization, hydrolysis, decarbonylation
and piperazination. The reaction temperature is moderate and the operation is easily
controlled. Additional four new compounds are prepared by the method.

关键词: ciprofloxacin;synthesis;quinolone

Abstract: A new synthetic method of ciprofloxacin is started with 2,4-dichloro-5-fluoroacetophenone,
via oxaly lation, ethoxymethylenation, amination, cyclization, hydrolysis, decarbonylation
and piperazination. The reaction temperature is moderate and the operation is easily
controlled. Additional four new compounds are prepared by the method.

Key words: ciprofloxacin, synthesis, quinolone

陈英奇, 戴立言. 环丙沙星合成的新方法[J]. CIESC Journal.

CHEN Yingqi, DAI Liyan. New Synthetic Method of Ciprofloxacin[J]. .

环丙沙星合成的新方法

New Synthetic Method of Ciprofloxacin

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