CIESC Journal

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通过通量平衡分析计算经验和真实维持系数

马红武; 赵学明; 郭晓峰   

  1. School of Chemical Engineering & Technology, Tianjin University, Tianjin 300072, China
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2002-02-28 发布日期:2002-02-28
  • 通讯作者: 马红武

Calculation of Empirical and True Maintenance Coefficients by Flux Balance Analysis

Ma Hongwu; Zhao Xueming; Guo Xiaofeng   

  1. School of Chemical Engineering & Technology, Tianjin University, Tianjin 300072, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2002-02-28 Published:2002-02-28
  • Contact: Ma Hongwu

摘要: The stoichiometric matrix of a simplified metabolic network in Bacillus Subtillis was
constructed from the flux balance equations, which were used for reconciliation of the
measured rates and determination of the inner metabolic rates. Thus more reliable results
of the true and empirical maintenance coefficients were obtained. The true maintenance
coefficient is linearly related to the specific growth rate and changes with the P/O ratio.
The measured biomass yield of adenosine triphosphate(ATP) is also linearly related to the
P/O ratio.

关键词: maintenance coefficient;flux balance analysis;metabolic network;biomass yield

Abstract: The stoichiometric matrix of a simplified metabolic network in Bacillus Subtillis was
constructed from the flux balance equations, which were used for reconciliation of the
measured rates and determination of the inner metabolic rates. Thus more reliable results
of the true and empirical maintenance coefficients were obtained. The true maintenance
coefficient is linearly related to the specific growth rate and changes with the P/O ratio.
The measured biomass yield of adenosine triphosphate(ATP) is also linearly related to the
P/O ratio.

Key words: maintenance coefficient, flux balance analysis, metabolic network, biomass yield