关键词: resolution;optimization;central composite rotatable design;modeling

Abstract: A response surface modeling approach for simultaneous optimization of optical purity and
yield wasapplied to the resolution of tartaric acid to study the effects of both the amount
of the solvent and the amountof the resolving agent α-methylbenzyl amine on the resolution
results. The direction of changing the experimen-tal conditions was determined from the
initial response study, and expected high yield of the pure L(+)-tartaricacid-L(-)-α-
methylbenzyl amine salt was obtained.

Key words: resolution, optimization, central composite rotatable design, modeling