Abstract: The complicated reaction system of methanol synthesis from CO ₂ and H ₂ in the reactor with silicone rubber/inorganic composite membrane was studied. In this paper, the effects of silicone rubber/ceramic composite membrane in the process of reaction of oxygen-containing compounds are investigated in detail through experimental work. Part of theoretical results is tested and verified, and the effects of process parameters on reaction behavior are also discussed. In the silicone rubber/ceramic composite membrane, the conversion of the main reaction increases by 22% against traditional fixed bed reaction. Experimental results also show that L _1,opt , the optimal nonuniform parameter of membrane permeation rate does exist.