Abstract: A kinetic model of two-step of methanol synthesis at lower temperature and pressure was derived on the basis of reaction mechanism in which different functions of two catalysts and adsorption methods were taken into account.Two reactions was concurrently analyzed for reaction mechanism,hence this kinetic model is useful in scale up.Model discrimination and parameter estimation were performed for the kinetics models of low temperature methanol synthesis on the basis of kinetic data measured in a stirred reactor.The results showed that the best model for fitting the experimental data is the model of 5-10 which takes into account that H ₂ is molecular adsorption,reaction is two-site adsorption reaction,and methanol desorption step is the rate determining step.The final model for methanol synthesis meets the requirement of statistic test(F-test) at 95% confidence level.The kinetic parameters for the final model agreed well with physical meaning.