Abstract: The paper develops a new idea to solve optimization problems that come from coexistence of two different kinds of uncertain parameters. Industrial Ecology (IE) and Eco-Industrial Park (EIP) is a new idea to deal with environmental problems. During the study on EIP,it is important to study the optimization of an industrial park under uncertainty.In an industrial park,uncertain parameters can be divided into two kinds:parameters of one kind are varying stochastically;and those of the other kind are varying periodically.There are methods for each kind of them. However,both kinds of parameters often exist at the same time in an industrial park.In this paper,the main steps to establish a framework to optimize an industrial park are presented.A method is developed to deal with problems of coexistence of both kinds of parameters.It converts periodical parameters to stochastic parameters, so that the problems can be solved by using stochastic optimization method. Finally an example is presented to testify the feasibility of the proposed method.