有机溶剂中树脂催化丙酮氰醇分解反应的动力学模型

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有机溶剂中树脂催化丙酮氰醇分解反应的动力学模型

章亭洲^a,b; 杨立荣^a; 朱自强^a; 吴坚平^a

^a College of Material & Chemical Engineering, Zhejiang University, Hangzhou 310027, China
^b College of Food Science, Biotechnology & Environmental Engineering, Hangzhou University
of Commerce, Hangzhou 310035, China

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2003-06-28 发布日期:2003-06-28
通讯作者: 章亭洲

Kinetic Model of Resin-Catalyzed Decomposition of Acetone Cyanohydrin in Organic Solvent

ZHANG Tingzhou^a,b; YANG Lirong^a; ZHU Ziqiang^a; WU Jianping^a

^a College of Material & Chemical Engineering, Zhejiang University, Hangzhou 310027, China
^b College of Food Science, Biotechnology & Environmental Engineering, Hangzhou University
of Commerce, Hangzhou 310035, China

Received:1900-01-01 Revised:1900-01-01 Online:2003-06-28 Published:2003-06-28
Contact: ZHANG Tingzhou

摘要/Abstract

摘要： Decomposition of acetone cyanohydrin is the first-step reaction for preparing (S)-α-cyano
-3-phenoxybenzyl alcohol (CPBA) by the one-pot method in organic media. Considering the
compatibility of bio-catalysts with chemical catalysts and the successive operation in the
bioreactor, anion exchange resin (D301) wasused as catalyst for this reaction. External
diffusion limitation was excluded by raising rotational speed to higherthan 190r@min-1 in
both solvents. Internal diffusion limitation was verified to be insignificant in this
reactionsystem. The effect of acetone cyanohydrin concentration on the reaction was also
investigated. An intrinsic kineticmodel was proposed when the mass transfer limitation was
excluded, and the average deviation of the model is10.5%.

关键词: acetone cyanohydrin;model;organic media;anion-exchange resin

Abstract: Decomposition of acetone cyanohydrin is the first-step reaction for preparing (S)-α-cyano
-3-phenoxybenzyl alcohol (CPBA) by the one-pot method in organic media. Considering the
compatibility of bio-catalysts with chemical catalysts and the successive operation in the
bioreactor, anion exchange resin (D301) wasused as catalyst for this reaction. External
diffusion limitation was excluded by raising rotational speed to higherthan 190r@min-1 in
both solvents. Internal diffusion limitation was verified to be insignificant in this
reactionsystem. The effect of acetone cyanohydrin concentration on the reaction was also
investigated. An intrinsic kineticmodel was proposed when the mass transfer limitation was
excluded, and the average deviation of the model is10.5%.

Key words: acetone cyanohydrin, model, organic media, anion-exchange resin

章亭洲, 杨立荣, 朱自强, 吴坚平. 有机溶剂中树脂催化丙酮氰醇分解反应的动力学模型[J]. CIESC Journal.

ZHANG Tingzhou, YANG Lirong, ZHU Ziqiang, WU Jianping. Kinetic Model of Resin-Catalyzed Decomposition of Acetone Cyanohydrin in Organic Solvent[J]. .

有机溶剂中树脂催化丙酮氰醇分解反应的动力学模型

Kinetic Model of Resin-Catalyzed Decomposition of Acetone Cyanohydrin in Organic Solvent

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