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7-氨基去乙酰氧基头孢菌素半间歇反应结晶过程

王静康; 刘越   

  1. The State R&D Center of Industrial Crystallization, School of Chemical Engineering and
    Technology, Tianjin University, Tianjin 300072, China
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2003-08-28 发布日期:2003-08-28
  • 通讯作者: 王静康

Semi-batch Crystallization of 7-Amino-Desacetoxycephalosporanic Acid

WANG Jingkang; LIU Yue   

  1. The State R&D Center of Industrial Crystallization, School of Chemical Engineering and
    Technology, Tianjin University, Tianjin 300072, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2003-08-28 Published:2003-08-28
  • Contact: WANG Jingkang

摘要: Semi-batch crystallization of 7-amino-desacetoxycephalosporanic acid (7-ADCA) is a
complicated pro-cess, in which agglomeration occurs together with nucleation and crystal
growth. To systematically study such aprocess, experiments were conducted to estimate the
crystallization thermodynamics and kinetics, and then theprocess was simulated by a
numerical method. The application of Monte Carlo concept in the algorithm to
describeagglomeration event offers an alternative approach of solving the population
balance, the intrinsic simplicity of whichallows us to investigate several mechanisms and
include several internal coordinates in the analysis. Furthermore,present study may be a
valuable paradigm for other semi-batch crystallization processes.

关键词: 7-ADCA;thermodynamics;kinetics;agglomeration;Monte Carlo simulation

Abstract: Semi-batch crystallization of 7-amino-desacetoxycephalosporanic acid (7-ADCA) is a
complicated pro-cess, in which agglomeration occurs together with nucleation and crystal
growth. To systematically study such aprocess, experiments were conducted to estimate the
crystallization thermodynamics and kinetics, and then theprocess was simulated by a
numerical method. The application of Monte Carlo concept in the algorithm to
describeagglomeration event offers an alternative approach of solving the population
balance, the intrinsic simplicity of whichallows us to investigate several mechanisms and
include several internal coordinates in the analysis. Furthermore,present study may be a
valuable paradigm for other semi-batch crystallization processes.

Key words: 7-ADCA, thermodynamics, kinetics, agglomeration, Monte Carlo simulation