黄孢原毛平革菌产酶的简化结构动力学模型

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黄孢原毛平革菌产酶的简化结构动力学模型

郑重鸣^a; FOO YinDin^a; Jeffery Philip Obbard^a; 林建平^b; 岑沛霖^b

^a Department of Chemical & Environmental Engineering, National University of Singapore, 10
Kent Ridge Crescent, Singapore 119260
^b Department of Chemical Engineering, Zhejiang University, Hangzhou 310027, China

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2003-08-28 发布日期:2003-08-28
通讯作者: 郑重鸣

A Simple Structure Model for Enzyme Production by Phanerochaete chrysosporium

ZHENG Zhongming^a; FOO YinDin^a; Jeffery Philip Obbard^a; LIN Jianping^b; CEN Peilin^b

^aDepartment of Chemical & Environmental Engineering, National University of Singapore, 10
Kent Ridge Crescent, Singapore 119260
^b Department of Chemical Engineering, Zhejiang University, Hangzhou 310027, China

Received:1900-01-01 Revised:1900-01-01 Online:2003-08-28 Published:2003-08-28
Contact: ZHENG Zhongming

摘要/Abstract

摘要： In order to understand the behavior of ligninolytic enzyme production by white rot fungi
Phanerochaetechrysosporium, study on time courses and a mathematical model for the
production of lignin peroxidase (LiP) andmanganese peroxidase (MnP) of the fungi was
undertaken. Based on the Monod-Jacob operon model, the ligninolyticenzyme would be
synthesized in the absence of a related repressor. The repressor is assumed to be active in
thepresence of ammonia nitrogen, and as combined as co-repressor, it causes the inhibition
of enzyme synthesis. Themodel can explain the mechanism of extracellular ligninolytic
enzyme production by white rot fungi. The results,as predicted by the model, correspond
closely to those observed in experimental studies. In addition, some lightis also shed on
unmeasured variables, such as the concentrations of repressor and mRNA that are related to
theenzyme synthesis.

关键词: secondary metabolite;lignin peroxidase (LiP);manganese peroxidase (MnP);model simulation;whiterot fungi;repressor;mRNA

Abstract: In order to understand the behavior of ligninolytic enzyme production by white rot fungi
Phanerochaetechrysosporium, study on time courses and a mathematical model for the
production of lignin peroxidase (LiP) andmanganese peroxidase (MnP) of the fungi was
undertaken. Based on the Monod-Jacob operon model, the ligninolyticenzyme would be
synthesized in the absence of a related repressor. The repressor is assumed to be active in
thepresence of ammonia nitrogen, and as combined as co-repressor, it causes the inhibition
of enzyme synthesis. Themodel can explain the mechanism of extracellular ligninolytic
enzyme production by white rot fungi. The results,as predicted by the model, correspond
closely to those observed in experimental studies. In addition, some lightis also shed on
unmeasured variables, such as the concentrations of repressor and mRNA that are related to
theenzyme synthesis.

Key words: secondary metabolite, lignin peroxidase (LiP), manganese peroxidase (MnP), model simulation, whiterot fungi, repressor

郑重鸣, FOO YinDin, Jeffery Philip Obbard, 林建平, 岑沛霖. 黄孢原毛平革菌产酶的简化结构动力学模型[J]. CIESC Journal.

ZHENG Zhongming, FOO YinDin, Jeffery Philip Obbard, LIN Jianping, CEN Peilin. A Simple Structure Model for Enzyme Production by Phanerochaete chrysosporium[J]. .

参考文献

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黄孢原毛平革菌产酶的简化结构动力学模型

A Simple Structure Model for Enzyme Production by Phanerochaete chrysosporium

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