关键词: imidacloprid;2-chloro-5-chloromethylpyridine;2-nitryliminoglyoxaline;technological optimization

Abstract: In order to reduce the production cost of imidacloprid, the preparation technology for the
direct combination of 2-chloro-5-chloromethylpyridine and 2-nitryliminoglyoxaline has been
optimized in a 10 L stirred tank reactor with a new solvent, butanone, and a new catalyst,
benzyl triethyl-ammonium chloride (BTEAC), which was proved to be more profitable for the
production of imidacloprid. Three main affecting factors (the reaction temperature, the
molar ratio of BTEAC to 2-nitryliminoglyoxaline and the concentration of 2-
nitryliminoglyoxaline) for the production of imidacloprid were investigated and the optimum
operating conditions were found. Based on the above technological optimization, an
industrial process for imidacloprid with a production capacity of 50 tons per year was put
in operation using a 2500 L stirred tank reactor under the same operating conditions. Good
yield and purity of imidacloprid was also obtained in the industrial production.

Key words: imidacloprid, 2-chloro-5-chloromethylpyridine, 2-nitryliminoglyoxaline, technological optimization