替考拉宁在不同液液萃取体系中分配系数的测定

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替考拉宁在不同液液萃取体系中分配系数的测定

陈勇^a; 徐志南^b; 金志华^a; 岑沛霖^a

^a Institute of Bioengineering, Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China ^b Department of Chemical Engineering, Universiti Teknologi Malaysia, 81310 UTM Skudai, Johor, Malaysia

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2004-08-28 发布日期:2004-08-28
通讯作者: 陈勇

Determination of Teicoplanin A2's Partition Coefficient in Different Liquid-Liquid Extraction Systems

CHEN Yong^a; XU Zhinan^b; JIN Zhihua^a; CEN Peilin^a

^a Institute of Bioengineering, Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China ^b Department of Chemical Engineering, Universiti Teknologi Malaysia, 81310 UTM Skudai, Johor, Malaysia

Received:1900-01-01 Revised:1900-01-01 Online:2004-08-28 Published:2004-08-28
Contact: CHEN Yong

摘要/Abstract

摘要： Teicoplanin is one of the macrocyclic glycopeptide antibiotics, which is active against Gram-positive bacteria, and has attracted a lot of attention in the field of chiral separation recently. In this work, the partition coefficients and extraction ratio of teicoplanin in three different solvent systemswere studied: conventional extraction, reactive extraction and reverse micelle extraction. With conventional solvent extraction, n-butanol demonstratedhigh partition coefficient for teicoplanin, but low extraction ratio because of its high solubility in water. Reactive extraction of teicoplanin showed the highest partition coefficient with almost 100% recovery in organic phase when tri-n-octylmethyl ammonium chloride (TOMAC) was used as extractant and pH value was above 5.0. A reverse micelle system, consisted of isooctane +10 mmol-L^-1 TOMAC -t-1% n-octanol, also offered high separation factor for teicoplanin. The results are beneficial for the design of teicoplanin separation and purification process.

关键词: 液-液萃取法;分离系数;TOMAC;胶态离子

Abstract: Teicoplanin is one of the macrocyclic glycopeptide antibiotics, which is active against Gram-positive bacteria, and has attracted a lot of attention in the field of chiral separation recently. In this work, the partition coefficients and extraction ratio of teicoplanin in three different solvent systemswere studied: conventional extraction, reactive extraction and reverse micelle extraction. With conventional solvent extraction, n-butanol demonstratedhigh partition coefficient for teicoplanin, but low extraction ratio because of its high solubility in water. Reactive extraction of teicoplanin showed the highest partition coefficient with almost 100% recovery in organic phase when tri-n-octylmethyl ammonium chloride (TOMAC) was used as extractant and pH value was above 5.0. A reverse micelle system, consisted of isooctane +10 mmol-L^-1 TOMAC -t-1% n-octanol, also offered high separation factor for teicoplanin. The results are beneficial for the design of teicoplanin separation and purification process.

Key words: ticoplanin, partition coefficients, conventional extraction, reverse micelle extraction

陈勇,徐志南,金志华,岑沛霖. 替考拉宁在不同液液萃取体系中分配系数的测定[J]. CIESC Journal.

CHEN Yong, XU Zhinan, JIN Zhihua, CEN Peilin. Determination of Teicoplanin A2's Partition Coefficient in Different Liquid-Liquid Extraction Systems[J]. .

替考拉宁在不同液液萃取体系中分配系数的测定

Determination of Teicoplanin A2's Partition Coefficient in Different Liquid-Liquid Extraction Systems

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