化工学报 ›› 2004, Vol. 55 ›› Issue (1): 74-80.

• 生物化学工程、制药、食品和天然产物加工 • 上一篇    下一篇

SA/CS-CaCl2/PMCG新型生物微胶囊的扩散与截留性能

张立央;姚善泾;关怡新   

  1. 浙江大学化学工程与生物工程学系, 浙江 杭州 310027
  • 出版日期:2004-01-25 发布日期:2004-01-25

DIFFUSION AND CUT-OFF CHARACTERISTICS OF SA/CS-CaCl2/PMCG MICROCAPSULES

ZHANG Liyang;YAO Shanjing;GUAN Yixin   

  • Online:2004-01-25 Published:2004-01-25

摘要: 通过测定不同相对分子质量的PEG传递透过SA/CS-CaCl2/PMCG生物微胶囊的性能,确定了SA/CS-CaCl2/PMCG膜的截留相对分子质量在2000左右。同时又测量了小分子物质葡萄糖、乳糖、乙醇和谷氨酸在3种SA/CS-CaCl2/PMCG微胶囊中的扩散性能,并用数学模型计算出了这些物质在不同微胶囊的混合扩散系数Dm以及相应的微胶囊膜层中扩散系数D1。结果表明: Dm随PMCG浓度的增大先增大而后呈减小趋势,而D1则随PMCG浓度的增大而增大;并且D1Dm,说明微胶囊中的传质阻力主要在微胶囊膜层中。

关键词:

扩散性能, 截留性能, SA/CS-CaCl2/PMCG生物微胶囊

Abstract: By measuring diffusion behavior of PEG with various molecular mass in SA/CS-CaCl2/PMCG microcapsules, it was shown that molecular mass cut-off of the microcapsules membrane was about 2000. Meanwhile, diffusion of small solutes including glucose, lactose, ethanol and L-glutamic acid in three kinds of SA/CS-CaCl2/PMCG microcapsules were determined. The mixed diffusion coefficients Dm and diffusion coefficients in capsular membrane D1 were calculated by a diffusion model. The results showed that the mixed diffusion coefficients Dm increased at first and subsequently slightly decreased with increasing concentration of PMCG, whereas D1 increased continuously. D1Dm indicated that the main resistance in mass transfer was mainly on the capsular membrane.

Key words:

扩散性能, 截留性能, SA/CS-CaCl2/PMCG生物微胶囊