关键词:

丙烯酰胺, 微生物转化, 反应分离耦合, 多级连续化反应

Abstract: Polysulfone hollow-fiber membrane was used and a continuous process of three-stage hollow-fiber membrane bioreactor system was designed for bio-convertion of acrylonitrile to acrylamide.On the basis of single stage membrane bioreactor,the feasibility of multiple-stage continuous process was discussed.At 20 ℃,the three-stage membrane bioreactor process steadily lasted over 80 h, the conversion of acrylonitrile was 99.9%, and the productivity was 25.3 g acrylamide•g cell^-1•h^-1. Comparing with the original batch reaction process,the productivity was enhanced by above 40%. With the hollow-fiber membrane, immobilized cells were replaced by free cells, and steady continuous process was achieved. This process has a favorable foreground in industrial application, which leads to continuous production of acylamide.

Key words:

丙烯酰胺, 微生物转化, 反应分离耦合, 多级连续化反应