Abstract: Elements including La, Ce and Bi were used to modify V-P oxide(VPO)catalyst which were used to catalyze cyclohexane oxidation in the liquid phase.Bi-VPO catalyst showed the best performance in liquid-phase oxidation.2 mmol of cyclohexane in 10 ml of acetonitrile could be well converted at 60℃ for 12 h by adding 3 ml (26 mmol) of H₂O₂, and 72% of cyclohexane conversion rate, 38% of cyclohexanone yield, and 34% of cyclohexanol yield were achieved with 0.01 g (V: 0.068 mmol) of Bi-VPO catalyst.Modified VPO catalysts could greatly enhance the catalytic performance in liquid-phase oxidation of cyclohexane.