Abstract: Mannich reaction of a series of aldehydes, ketones and amines catalyzed by Bronsted acid ionic liquids (ILs) was investigated.1-butyl-3-methylimidazolium tetrafluoroborate (BMImBF₄) /1-butyl-3- methylimidazolium dihydrogen phosphate (BMImH₂PO₄) and 1-ethylimidazolium trifluoroacetic acid (HEImTA) were chosen as reaction media.Shorter reaction time and the excellent yield were obtained as compared with the traditional processes.Product isolation was easy (by hydrolysis of reaction mixture and subsequent filtration), and the acid ionic liquids (also acting as a catalyst) could be easily to be recycled efficiently.The application scope of the established process was also discussed.