Abstract: A pigging model incorporating three different regions was developed for predicting the dynamics of the pigging operation in two-phase flow pipelines. The model incorporates a transient two-fluid model.The mixed Eulerean-Lagrangian approach was used to couple the transient model and the pigging model which can predict the pigging time, velocity and the change of pigging parameters. An experimental study was carried out to acquire two-phase transient flow and pigging data on a 380m long,81mm diameter horizontal pipeline. A computer-based data acquisition system was used to obtain detailed information of the flow behavior during experimental runs. The data include pigging time, inlet pressure, accumulated liquid in pipeline, pressure and pigging velocity distribution.The predicted results compared fairy well with the experimental data.