Abstract: Synergetic analysis was used for modeling complex reaction kinetics.The synthesis of ethyl tert-amyl ether(TAEE) was chosen as a model system.tert-Amyl alcohol and ethanol were raw materials, and the strong acid cationic exchange resin NKC-29 was used as catalysts.The experiments were carried out in liquid phase under atmospheric condition, and temperature range was from 313 K to 323 K. Haken’s formulations were obtained by a non-singularity transformation of the reaction rate differential equations. Using the adiabatic elimination method, the evolutional relations of reaction order parameters could be obtained. The proposed method avoided solving the complex kinetics differential equations and reduced the number of parameters.Variance analysis proved that the calculated results of the synergetic method agreed well with the experimental results.The values of reaction activation energy were also in a reasonable range.