Abstract: Some successful vapor-liquid equilibrium(VLE) mixing rules based on excess free energy models proposed in recent years combines the advantages owned partially by equations of state and activity coefficient models to obtain the better prediction for nonpolar and polar systems.The paper coupled with the merits of MHV1 mixing rule, LCVM mixing rule and WS mixing rule to put forward the new two-parameter mixing rule which satisfies the second viral coefficient boundary condition.The new mixing rule, coupled with the PR equation of state and the NRTL model is tested against 18 kinds of vapor-liquid equilibrium data of nonpolar, nonpolar-polar/polar-nonpolar,and polar-polar systems.The test results indicate that the new model can yield better prediction.Compared to the other two mixing rules (WS,MHV1), the new model shows better VLE prediction capabilities of binary mixtures.