(S)-(+)-2,2-二甲基环丙烷甲酰胺在不同溶剂中溶解度的测定与关联

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(S)-(+)-2,2-二甲基环丙烷甲酰胺在不同溶剂中溶解度的测定与关联

石晓华^a,b; 周彩荣^b; 高玉国^b; 陈新志^a

^a College of Materials Science and Chemical Engineering, Zhejiang University, Hangzhou 310027, China
^b College of Chemical Engineering, Zhengzhou University, Zhengzhou 450002, China

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2006-08-28 发布日期:2006-08-28
通讯作者: 石晓华

Measurement and Correlation for Solubility of (S)-(+)-2,2-Dimethyl- cyclopropane Carbox Amide in Different Solvents

SHIXiaohua^a,b;ZHOUCairong^b; GAOYuguo^b; CHENXin-zhi^a

^aCollege of Materials Science and Chemical Engineering, Zhejiang University, Hangzhou 310027, China
^b College of Chemical Engineering, Zhengzhou University, Zhengzhou 450002, China

Received:1900-01-01 Revised:1900-01-01 Online:2006-08-28 Published:2006-08-28
Contact: SHI Xiaohua

摘要/Abstract

摘要： (S)-(+)-2,2-dimethylcyclopropane carbox amide is a key intermediate of Cilastatin, an inhibitor of de-hydropeptidase-I. Its corresponding solid-liquid equilibrium data will provide essential support for industrial design and further theoretical studies. The solubilities of (S)-(+)-2,2-dimethylcyclopropane carbox amide in toluene, di-chloromethane, trichloromethane, ethyl acetate, ethanol and pure water at different temperature were measured us-ing the synthetic method by a laser monitoring observation technique. The solubility data were correlated with the modified Apelblat equation. The calculated values were good in agreement with the experimental values.

关键词: solid-liquid equilibrium;solubility;(S)-(+)-2;2-dimethylcyclopropane carbox amide

Abstract: (S)-(+)-2,2-dimethylcyclopropane carbox amide is a key intermediate of Cilastatin, an inhibitor of de-hydropeptidase-I. Its corresponding solid-liquid equilibrium data will provide essential support for industrial design and further theoretical studies. The solubilities of (S)-(+)-2,2-dimethylcyclopropane carbox amide in toluene, di-chloromethane, trichloromethane, ethyl acetate, ethanol and pure water at different temperature were measured us-ing the synthetic method by a laser monitoring observation technique. The solubility data were correlated with the modified Apelblat equation. The calculated values were good in agreement with the experimental values.

Key words: solid-liquid equilibrium, solubility, (S)-(+)-2, 2-dimethylcyclopropane carbox amide

石晓华, 周彩荣, 高玉国, 陈新志. (S)-(+)-2,2-二甲基环丙烷甲酰胺在不同溶剂中溶解度的测定与关联[J]. CIESC Journal.

SHIXiaohua,ZHOUCairong, GAOYuguo, CHENXin-zhi. Measurement and Correlation for Solubility of (S)-(+)-2,2-Dimethyl- cyclopropane Carbox Amide in Different Solvents[J]. .

参考文献

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(S)-(+)-2,2-二甲基环丙烷甲酰胺在不同溶剂中溶解度的测定与关联

Measurement and Correlation for Solubility of (S)-(+)-2,2-Dimethyl- cyclopropane Carbox Amide in Different Solvents

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