Abstract: In this study, Ce1-xCuxO2-x/Al2O3（x=0—1）solid solution catalysts and Ce0.2Cu0.8O1.2/Al2O3 catalysts with different Ce0.2Cu0.8O1.2 loading were prepared with the co-impregnation method. The catalysts were characterized by means of X-ray diffraction（XRD）and temperature-programmed reduction（TPR）. It was found that some of the Ce1-xCuxO2-x/Al2O3 catalysts exhibited high activity for catalytic combustion of methane because of the formation of the solid solution which promoted the dispersion of Cu, and changed redox property of the catalyst.There existed synergetic effect between CeO2 and CuO and the mole ratio of Ce to Cu influenced the activity of the catalyst.