Abstract: A new method was developed for the fabrication of porous ceramics by using the special three-dimensional reticulate framework formed by the groups of flocculent raw particles in the deposit. The size of pore diameter could be controlled between micron and nanometer scale. For the former, the pore diameter was about 10 to 100 μm, the apparent porosity ranged from 53 % to 59 %,the bulk density from 0.97 to 1.10 g•cm^-3, and the crushing strength above 6.0 MPa; for the latter, measured by the mercury intrusion method, the average pore diameter was about 76 nm, and the total surface area 5.90 m2•g^-1. With commercial Penicillium expansum lipase(PEL) as model enzyme, the performance of the porous ceramic supports was investigated in relation to the activity and stability of immobilized enzyme. The results indicated that the microporous ceramics prepared by the present method could potentially be better inorganic supports for enzyme immobilization than some other commercial inorganic solid supports like silica gel, diatomite and active carbon, on the condition that its pore surface was suitably modified according to the property of the enzyme.