CIESC Journal

• BIOTECHNOLOGY & BIOENGINEERING • 上一篇    下一篇

电致孔经皮给药:表面活性剂对孔道存在时间和药物传输的影响

蒋国强; 朱德权; 昝佳; 丁富新   

  1. Department of Chemical Engineering, Tsinghua University, Beijing 100084, China
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2007-06-28 发布日期:2007-06-28
  • 通讯作者: 蒋国强

Transdermal drug delivery by electroporation: The effects of surfactants on pathway
lifetime and drug transport

JIANG Guoqiang; ZHU Dequan; ZAN Jia; DING Fuxin   

  1. Department of Chemical Engineering, Tsinghua University, Beijing 100084, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2007-06-28 Published:2007-06-28
  • Contact: JIANG Guoqiang

摘要: Electroporation creates aqueous pathways by short high-voltage pulses resulting in a
transient permeabilization of stratum corneum and an increase in the transdermal delivery
rate. However the aqueous pathways will reseal after pulsing, which leads to the rapid drop
of transdermal flux. In the present study, the surfactants were added to the donor solution
to hinder the shrinkage and resealing of the electropore, and to prolong the lifetime of
the aqueous pathways with the consideration that the surfactants could reduce the surface
energy of the electropore. These effects of surfactants were demonstrated by the dynamic
electrical resistance of the skin and the fluorescent imaging of the local transport
regions. Piroxicam (PIX) was transported percutaneously in the presence of surfactants in
vitro. Owing to the longer lifetime of aqueous pathways, together with the promotion of PIX
availability at the barrier exterior and the improvement in the partition of PIX into the
aqueous pathways, the presence of surfactants led to a remarkable increase in the
transdermal delivery rate during electroporation and a significant growth of the
accumulative transdermal amount of PIX.

关键词: transdermal drug delivery;skin electroporation;surfactant;aqueous pathway

Abstract: Electroporation creates aqueous pathways by short high-voltage pulses resulting in a
transient permeabilization of stratum corneum and an increase in the transdermal delivery
rate. However the aqueous pathways will reseal after pulsing, which leads to the rapid drop
of transdermal flux. In the present study, the surfactants were added to the donor solution
to hinder the shrinkage and resealing of the electropore, and to prolong the lifetime of
the aqueous pathways with the consideration that the surfactants could reduce the surface
energy of the electropore. These effects of surfactants were demonstrated by the dynamic
electrical resistance of the skin and the fluorescent imaging of the local transport
regions. Piroxicam (PIX) was transported percutaneously in the presence of surfactants in
vitro. Owing to the longer lifetime of aqueous pathways, together with the promotion of PIX
availability at the barrier exterior and the improvement in the partition of PIX into the
aqueous pathways, the presence of surfactants led to a remarkable increase in the
transdermal delivery rate during electroporation and a significant growth of the
accumulative transdermal amount of PIX.

Key words: transdermal drug delivery, skin electroporation, surfactant, aqueous pathway