CIESC Journal

• BIOTECHNOLOGY & BIOENGINEERING • 上一篇    下一篇

高含量β-胡萝卜素微胶囊干粉流动性的考察及其影响因素

许新德a,b; 姚善泾a; 韩宁a; 邵斌b   

  1. a Department of Chemical and Biochemical Engineering, Zhejiang University, Hangzhou 310027,
    China
    b Xinchang Pharma. Factory, Zhejiang Medical Co. Ltd., Xinchang 312500, China
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2007-08-28 发布日期:2007-08-28
  • 通讯作者: 许新德

Measurement and influence factors of the flowability of microcapsules with high-content β
-carotene

XU Xindea,b; YAO Shanjinga; HAN Ninga; SHAO Binb   

  1. a Department of Chemical and Biochemical Engineering, Zhejiang University, Hangzhou 310027,
    China
    b Xinchang Pharma. Factory, Zhejiang Medical Co. Ltd., Xinchang 312500, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2007-08-28 Published:2007-08-28
  • Contact: XU Xinde

摘要: The flowability of five kinds of microencapsulation powders, with different β-carotene
contents and by two alternative particle-forming technologies i.e. spray-drying and starch
-catching beadlet technology, was meas-ured. The actual flow properties of the five powders
were compared based on bin-flow test, and three flow indexes (Hausner ratio, repose angle
and flow index) were measured. It was found that the repose angle is the most suitable
index to reflect the flowability of these powders for the particle properties would not be
altered due to compaction or tapping during the measuring process. Particle size and
particle size distribution play most important roles in the flowability of these granular
materials, which was also influenced by other factors like shape, surface texture, sur-face
roughness, etc. Microcapsules with wall material of gelatin and a layer of modified starch
absorbed on the sur-face showed excellent flowabilities and good mechanical properties, and
they are favorable for tabletting to supply β-carotene.

关键词: β-carotene;microcapsule powders;flowability;Hausner ratio;repose angle

Abstract: The flowability of five kinds of microencapsulation powders, with different β-carotene
contents and by two alternative particle-forming technologies i.e. spray-drying and starch
-catching beadlet technology, was meas-ured. The actual flow properties of the five powders
were compared based on bin-flow test, and three flow indexes (Hausner ratio, repose angle
and flow index) were measured. It was found that the repose angle is the most suitable
index to reflect the flowability of these powders for the particle properties would not be
altered due to compaction or tapping during the measuring process. Particle size and
particle size distribution play most important roles in the flowability of these granular
materials, which was also influenced by other factors like shape, surface texture, sur-face
roughness, etc. Microcapsules with wall material of gelatin and a layer of modified starch
absorbed on the sur-face showed excellent flowabilities and good mechanical properties, and
they are favorable for tabletting to supply β-carotene.

Key words: β-carotene, microcapsule powders, flowability, Hausner ratio, repose angle