溶剂与杂质对11α-羟基-16α,17α-环氧黄体酮晶习的影响

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溶剂与杂质对11α-羟基-16α,17α-环氧黄体酮晶习的影响

聂强; 王静康; 王永莉; 鲍颖

School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China

收稿日期:2006-11-20 修回日期:1900-01-01 出版日期:2007-10-28 发布日期:2007-10-28
通讯作者: 聂强

Effects of solvent and impurity on crystal habit modification of 11α-hydroxy-16α,17α-epoxyprogesterone

NIE Qiang; WANG Jingkang; WANG Yongli; BAO Ying

School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China

Received:2006-11-20 Revised:1900-01-01 Online:2007-10-28 Published:2007-10-28
Contact: NIE Qiang

摘要/Abstract

摘要： The effects of solvent and impurity on the crystal habit of 11α-hydroxy-16α, 17α-epoxyprogesterone (HEP) grown from solution were studied by scanning electron microscope. Long prismatic crystals were produced when HEP was crystallized from pure acetone and N,N-dimethylformamide, while blocky crystals were produced from pure chloroform by cooling crystallization. One kind of isomorphic impurity, 16α,17α-epoxyprogesterone (EP) was selected to examine its effect on the HEP crystal habit. When the content of EP in the mother liquor is very high (55.45%, solvent free basis), the habit of produced HEP crystals was greatly modified from prismatic to octahedral. The differential scanning calorimetry and X-ray powder diffraction analyses showed that the change of crystal habit was originated from the crystal structure modification.

关键词: crystal habit;crystal structure;crystal growth;11α-hydroxy-16α;17α-epoxyprogesterone

Abstract: The effects of solvent and impurity on the crystal habit of 11α-hydroxy-16α, 17α-epoxyprogesterone (HEP) grown from solution were studied by scanning electron microscope. Long prismatic crystals were produced when HEP was crystallized from pure acetone and N,N-dimethylformamide, while blocky crystals were produced from pure chloroform by cooling crystallization. One kind of isomorphic impurity, 16α,17α-epoxyprogesterone (EP) was selected to examine its effect on the HEP crystal habit. When the content of EP in the mother liquor is very high (55.45%, solvent free basis), the habit of produced HEP crystals was greatly modified from prismatic to octahedral. The differential scanning calorimetry and X-ray powder diffraction analyses showed that the change of crystal habit was originated from the crystal structure modification.

Key words: crystal habit, crystal structure, crystal growth, 11α-hydroxy-16α, 17α-epoxyprogesterone

聂强, 王静康, 王永莉, 鲍颖. 溶剂与杂质对11α-羟基-16α,17α-环氧黄体酮晶习的影响[J]. CIESC Journal.

NIE Qiang, WANG Jingkang, WANG Yongli, BAO Ying. Effects of solvent and impurity on crystal habit modification of 11α-hydroxy-16α,17α-epoxyprogesterone[J]. .

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溶剂与杂质对11α-羟基-16α,17α-环氧黄体酮晶习的影响

Effects of solvent and impurity on crystal habit modification of 11α-hydroxy-16α,17α-epoxyprogesterone

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