超临界CO2萃取穿心莲内酯的实验研究

CIESC Journal

• SEPARATION SCIENCE & ENGINEERING • 上一篇下一篇

超临界CO2萃取穿心莲内酯的实验研究

A.C. Kumoro¹; Masitah Hasan²

¹ Department of Chemical Engineering, Faculty of Engineering, Diponegoro University, SH Road, Tembalang Se-marang 50139, Indonesia
² Department of Chemical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur 50603, Malaysia

收稿日期:2006-09-29 修回日期:1900-01-01 出版日期:2007-12-28 发布日期:2007-12-28
通讯作者: A.C. Kumoro

Supercritical carbon dioxide extraction of andrographolide from Andrographis paniculata: Effect of the solvent flow rate, pressure and temperature

A.C. Kumoro¹; Masitah Hasan²

¹ Department of Chemical Engineering, Faculty of Engineering, Diponegoro University, SH Road, Tembalang Se-marang 50139, Indonesia
² Department of Chemical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur 50603, Malaysia

Received:2006-09-29 Revised:1900-01-01 Online:2007-12-28 Published:2007-12-28
Contact: A.C. Kumoro

摘要/Abstract

摘要： Andrographis paniculata Nees has been extensively used for traditional medicine and help against fever, dysentery, diarrhoea, inflammation, and sore throat. In this study, andrographolide, the main component of this plant was extracted from the leaves of A. paniculata using supercritical carbon dioxide. The operating pressures were varied from 7.50 to 20MPa, the temperatures were varied from 30℃ to 60℃, and the flow rates were varied from 0.5 to 4ml•min－1. The best extraction condition occurred at 10MPa, 40℃, and a flow rate of 2ml•min－1 for a 3g sample of A. paniculata ground-dried leaves. The measured extraction rate was found to be about 0.0174g of andrographolide per gram of andrographolide present in the leaves per hour of operation. The future studies must focus on the interaction between the various operating parameters such as temperature, pressure, and flow rate of supercritical carbon dioxide.

关键词: supercritical carbon dioxide;extraction;andrographolide;Andrographis paniculata

Abstract: Andrographis paniculata Nees has been extensively used for traditional medicine and help against fever, dysentery, diarrhoea, inflammation, and sore throat. In this study, andrographolide, the main component of this plant was extracted from the leaves of A. paniculata using supercritical carbon dioxide. The operating pressures were varied from 7.50 to 20MPa, the temperatures were varied from 30℃ to 60℃, and the flow rates were varied from 0.5 to 4ml•min－1. The best extraction condition occurred at 10MPa, 40℃, and a flow rate of 2ml•min－1 for a 3g sample of A. paniculata ground-dried leaves. The measured extraction rate was found to be about 0.0174g of andrographolide per gram of andrographolide present in the leaves per hour of operation. The future studies must focus on the interaction between the various operating parameters such as temperature, pressure, and flow rate of supercritical carbon dioxide.

Key words: supercritical carbon dioxide, extraction, andrographolide, Andrographis paniculata

A.C. Kumoro, Masitah Hasan. 超临界CO2萃取穿心莲内酯的实验研究[J]. CIESC Journal.

A.C. Kumoro, Masitah Hasan. Supercritical carbon dioxide extraction of andrographolide from Andrographis paniculata: Effect of the solvent flow rate, pressure and temperature[J]. .

参考文献

1 Wongkittipong, R., Prat, L., Damronglerd, S., Gourdon, C., “Solid-liquid extraction of andrographolide from plants-experimental study, kinetic reaction and model”, Sep. Purif. Technol., 40, 147—154(2000).
2 Calabrese, C., Berman, S.H., Babish, J.G., “A phase I trial of andrographolide in HIV positive patients and normal volunteers”, Phytother. Res., 14, 333—338(2000).
3 Choudhury, B.R., Haque, S.J., Poddar, M.K., “In vivo and in vitro effects of kalmegh (Andrographis paniculata) extract and andrographolide on hepatic microsomal drug metabolising enzymes”, Planta Med., 53, 135—140(1987).
4 Rajani, M., Shrivastava, N., Ravishankara, M.N., “A rapid method for isolation of andrographolide from An-drographis paniculata Nees (Kalmegh)”, Pharmaceut. Biol., 38, 204—209(2000).
5 Tonthubthimthong, P., Chuaprasert, S., Douglas, P., Luewisutthichat, W., “Supercritical CO2 extraction of nimbin from neem seeds—An experimental study”, J. Food Eng., 47, 289—293(2001).
6 Jarvis, A.P., Morgan, E.D., “Isolation of plant products by supercritical-fluid extraction”, Phytochem. Anal., 8, 217—2221997).
7 Roy, B.C., Goto, M., Kodama, A., Hirose, T., “Super-critical CO2 extraction of essential oils and cuticular waxes from peppermint leaves”, J. Chem.Technol. Bio-technol., 67, 21—26(1996).
8 Ge, F.H., Lin, X.X., Huan, X.F., Shi, Q., Liang, B., Li, J., Zhong, G., “Study on extraction of active ingredients from Andrographis paniculata using orthogonal experi-ment with supercritical carbon dioxide”, J. Chinese Med. Mater., 25(2), 101—102(2002). (in Chinese)
9 Elkanzi, E.M., Singh, H., “ Extraction of used lubricating oils with supercritical carbon dioxide”, Arabian J. Sci. Eng., 26(2C), 11—23(2001).
10 Tonthubthimthong, P., Douglas, P.L., Douglas, S., Luewisutthichat, W., Teppaitoon, W., Pengsopa, L., “Ex-traction of nimbin from neem seeds using supercritical CO2 and a supercritical CO2-methanol mixture”, J. Su-percrit. Fluids, 30, 287—301(2004).
11 Saldana, M.D.A., Zetzl, C., Mohamed, R.S., Brunner, G. , “Decaffeination of guaraná seeds in a microextraction column using water-saturated CO2”, J. Supercrit. Fluids, 22, 119—127(2002).
12 Macnaughton, S.J., Foster, N.R., “ Supercritical adsorp-tion and desorption behaviour of DDT on activated car-bon using carbon dioxide”, Ind. Eng. Chem. Res., 34, 275—282(1995).
13 Goto, M., Sato, M., Hirose, T., “Extraction of peppermint oil by supercritical carbon dioxide”, J. Chem. Eng. Japan, 26(4), 401—407(1993).
14 Goto, M., Roy, B.C., Kodama, A., Hirose, T. , “Model-ling supercritical fluid extraction process involving sol-ute-solid interaction”, J. Chem. Eng. Japan, 31(2), 171—177(1998).
15 Vetere, A., “A short-cut method to predict the solubilities of solids in supercritical carbon dioxide”, Fluid Phase Equil., 148, 83—93(1998).
16 Lucas, S., Calvo, M.P., Palencia, C., Cocero, M.J., “Mathematical model of supercritical CO2 adsorption on activated carbon: Effect of operating conditions and ad-sorption scale-up”, J. Supercrit. Fluids, 32, 193—201(2004).
17 Doker, O., Salgin, U., Sanal, I., Mehmetoglu, U., Calimli, A., “Modelling of extraction of -carotene from apricot bagasse using supercritical CO2 in packed bed extractor”, J. Supercrit. Fluids, 28, 11—19(2004).
18 Marentis, R.T., “Steps to developing a commercial su-percritical carbon dioxide processing plant”, In: Super-critical Fluid Extraction and Chromatography, Carpentier, B.A., Sevenants, M.R., eds., American Chemical Society, Washington, DC (1988).
19 Roy, B.C., Goto, M., Hirose, T., “Extraction of ginger oil with supercritical carbon dioxide: experiments and mod-eling”, Ind. Eng. Chem. Res., 35, 607—612(1996).
20 Span, R., Wagner, W., ”A new equation of state carbon dioxide covering the region from triple-point temperature to 1100K at pressure up to 800MPa.”, J. Phys. Chem. Ref. Data, 25(6), 1509—1596(1996).
21 Jossi, J.A., Stiel, L.I., Thodos, G., “The viscosity of pure substances in the dense gaseous and liquid phases”, AIChE J., 8(1), 59—62(1962).
22 Liu, H., Silva, C.M., Macedo, E.A., “Unified approach to the self-diffusion coefficients of dense fluids over wide ranges of temperature and pressure-hard-sphere, square-well, Lennard-Jones and real substances”, Chem. Eng. Sci., 53(13), 2403—2422(1998).
23 Baysal, T., Starmans, D.A.J., “Supercritical carbon diox-ide extraction of carvone and limonene from caraway seed”, J. Supercrit. Fluids, 14, 225—234(1999).
24 de Franca, L.F., Reber, G., Meireles, M.A.A., Machado, N.T., Brunner, G., “Supercritical extraction of carote-noids and lipids from buriti (Mauritia flexuosa), a fruit from the Amazon region”, J. Supercrit.Fluids, 14, 247—256(1999).
25 D’Andrea, A., Ferri, D., Maccioni, O., van der Esch, S.A., Vitali, F., “Application of SFE technology to the extrac-tion of active substances from Azadirachta indica (A. juss) seeds”, Kleeburg, H., eds., In: Practice Oriented Results on the Use and Production of Neem Ingredients and Pheromones”, Drug und Graphic, Giessen (1994).
26 Brunner, G., Birtich, A., Johannsen, M., “Supercritical fluid extraction of oil-palm components”, J. Supercrit. Fluids, 8, 46—50(1995).
27 de Lucas, A., de la Ossa, E.M., Rincón, J., Blanco, M.A., Gracia, I., “Supercritical fluid extraction of tocopherol concentrates from olive tree leaves”, J. Supercrit. Fluids, 22, 221—228(2002).
28 Yang, Y., Gharaibeh, A., Hawthorne, S.B., Miller, D.J., “Combined temperature & modifier effects on super-critical CO2 extraction efficiencies of polycyclic aromatic hydrocarbons from environmental samples”, Anal. Chem., 67(3), 641—646(1995).
29 Kiriamiti, H.K., Rascol, E., Marty, A., Condoret, J.S., “Extraction rates of oil from high oleic sunflower seeds with supercritical carbon dioxide”, Chem. Eng. Process., 41, 711—718(2002).
30 Vetere, A., “A short-cut method to predict the solubilities of solids in supercritical carbon dioxide”, Fluid Phase Equilib., 148, 83—93(1998).
31 Skerget, M., Knez, Z., “Modelling high pressure extraction processes”, Comp. Chem. Eng., 25, 879—886(2001).

超临界CO2萃取穿心莲内酯的实验研究

Supercritical carbon dioxide extraction of andrographolide from Andrographis paniculata: Effect of the solvent flow rate, pressure and temperature

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 0

编辑推荐

Metrics

本文评价